Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.46 |
| ▸ | CNR2 | P34972 | 5/20 | 0.37 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.35 |
| ▸ | CCR2 | P41597 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366003 | 0.80 | HRH3 (0.53) | HRH3 | |
| SCHEMBL4365923 | 0.79 | HRH3 (0.59) | HRH3PADI4 | |
| SCHEMBL3539771 | 0.70 | HRH3 (0.63) | HRH3PTGS1PTGS2 | |
| SCHEMBL2768671 | 0.68 | HRH3 (0.64) | HRH3CCR2PTGS1PTGS2 | |
| SCHEMBL3538545 | 0.67 | HRH3 (0.71) | HRH3PTGS1PTGS2 | |
| SCHEMBL23052993 | 0.66 | NOD2 (0.64) | CCR2 | |
| SCHEMBL4373527 | 0.65 | HRH3 (0.44) | HRH3CNR2 | |
| SCHEMBL3542210 | 0.63 | HRH3 (1.00) | HRH3CNR2 | |
| SCHEMBL3544224 | 0.62 | HRH3 (0.95) | HRH3CNR2 | |
| SCHEMBL30121932 | 0.62 | ALDH1A1 (0.56) | CNR2CCR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |