Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 10/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699327 | 0.90 | ALDH1A1 (0.78) | PLA2G2AKDM4EPLA2G1BALDH1A1TSHR | |
| SCHEMBL7676057 | 0.89 | LTB4R (0.67) | PLA2G2AKDM4EALDH1A1POLBGAA | |
| SCHEMBL10840421 | 0.88 | PLA2G2A (0.62) | PLA2G2AKDM4EPLA2G1BALDH1A1TSHR | |
| SCHEMBL336644 | 0.84 | PLA2G2A (0.61) | PLA2G2AKDM4EPLA2G1BALDH1A1TSHR | |
| SCHEMBL290852 | 0.83 | GAA (0.79) | PLA2G2AKDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL6820689 | 0.83 | PLA2G2A (0.68) | PLA2G2APLA2G1BALDH1A1TSHRKMT2A | |
| SCHEMBL7963016 | 0.83 | PLA2G2A (1.00) | PLA2G2AKDM4EPLA2G1BALDH1A1TSHR | |
| SCHEMBL3388126 | 0.82 | PLA2G2A (0.68) | PLA2G2AKDM4EALDH1A1TSHRKMT2A | |
| SCHEMBL10778316 | 0.82 | MAPT (0.59) | PLA2G2AKDM4EALDH1A1TSHRKMT2A | |
| SCHEMBL612585 | 0.81 | POLB (0.62) | PLA2G2AKDM4EALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629353-B2 | Indol-3-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists | HOFFMAN-LA ROCHE INC. (US) | 2009-12-08 | — | — | US | disclosed |
| EP-1904477-B1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2009-01-21 | — | — | EP | disclosed |
| US-20080146557-A1 | INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS VIa RECEPTOR ANTAGONISTS | BISSANTZ CATERINA | 2008-06-19 | — | — | US | disclosed |
| US-7332501-B2 | Indol-3-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-20070027173-A1 | Indol-3-yl-carbonyl-spiro-piperidine derivatives as Vla receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027173-A1 | Indol-3-yl-carbonyl-spiro-piperidine derivatives as Vla receptor antagonists | AVPR1A, AVPR2, AVPR1B | PLA2G2A 2345/4885KDM4E 3141/4885PLA2G1B 3360/4885 |
| US-20080146557-A1 | INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS VIa RECEPTOR ANTAGONISTS | AVPR1A, AVPR2, OXTR | PLA2G2A 3693/4885KDM4E 3012/4885PLA2G1B 4239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.