Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 17/20 | 0.73 |
| ▸ | BCHE | P06276 | 16/20 | 0.73 |
| ▸ | APP | P05067 | 3/20 | 0.59 |
| ▸ | MAOB | P27338 | 3/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373839 | 1.00 | ACHE (0.73) | ACHEBCHEAPPMAOBCHRM2 | |
| SCHEMBL13876832 | 1.00 | ACHE (0.73) | ACHEBCHEAPPMAOBCHRM2 | |
| Memoquin SCHEMBL29416823 | 1.00 | ACHE (0.73) | ACHEBCHEAPPMAOBCHRM2 | |
| SCHEMBL13876830 | 0.99 | ACHE (0.71) | ACHEBCHEAPPMAOBCHRM2 | |
| SCHEMBL4370571 | 0.95 | BCHE (0.65) | ACHEBCHEAPPMAOB | |
| SCHEMBL4371900 | 0.95 | ACHE (0.66) | ACHEBCHEAPPMAOBCHRM2 | |
| SCHEMBL4543965 | 0.95 | ACHE (0.66) | ACHEBCHEAPPMAOBCHRM2 | |
| SCHEMBL4372983 | 0.95 | ACHE (0.66) | ACHEBCHEAPPMAOBCHRM2 | |
| SCHEMBL13890778 | 0.94 | BCHE (0.65) | ACHEBCHEAPPMAOB | |
| SCHEMBL13706588 | 0.91 | ACHE (0.67) | ACHEBCHEAPPMAOBCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261345-A1 | 2,5-Bis-diamine-'1,4! benzoquinone derivatives, for the treatment of alzheimer's disease a process for their preparation and intermediates therefor | ALMA MATER STUDIORUM-UNIVERSITA' DI BOLOGNA (IT) | 2005-11-24 | — | — | US | claimed |
| US-7589219-B2 | 2,5-bis-diamine-[1,4]benzoquinonic derivatives, useful for the treatment of alzheimer's disease, method for preparing them and intermediates of said method | ALMA MATER STUDIORUM-UNIVERSITA' DI BOLOGNA (IT) | 2009-09-15 | — | — | US | disclosed |
| US-20090093521-A1 | 2, 5-Bis-Diamine [1,4] Benzoquinone-Derivatives | ALMA MATER STUDIORUM - UNIVERISTA'DI BOLOGNA (IL) | 2009-04-09 | — | — | US | disclosed |
| US-20090093521-A1 | 2, 5-Bis-Diamine [1,4] Benzoquinone-Derivatives | ALMA MATER STUDIORUM - UNIVERISTA'DI BOLOGNA (IL) | 2009-04-09 | — | — | US | disclosed |
| US-20050261345-A1 | 2,5-Bis-diamine-'1,4! benzoquinone derivatives, for the treatment of alzheimer's disease a process for their preparation and intermediates therefor | ALMA MATER STUDIORUM-UNIVERSITA' DI BOLOGNA (IT) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261345-A1 | 2,5-Bis-diamine-'1,4! benzoquinone derivatives, for the treatment of alzheimer's disease a process for their preparation and intermediates therefor | PSEN2, BACE2, WEE2 | ACHE 169/4885BCHE 77/4885APP 16/4885 |
| US-20090093521-A1 | 2, 5-Bis-Diamine [1,4] Benzoquinone-Derivatives | POLQ, DDX5, SDHA | ACHE 2842/4885BCHE 2356/4885APP 3616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.