Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 12/20 | 0.69 |
| ▸ | P2RX1 | P51575 | 11/20 | 0.67 |
| ▸ | P2RX4 | Q99571 | 6/20 | 0.67 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | IKBKB | O14920 | 1/20 | 0.67 |
| ▸ | CHUK | O15111 | 1/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.67 |
| ▸ | FLT3 | P36888 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | MYLK | Q15746 | 1/20 | 0.67 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.67 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.60 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.59 |
| ▸ | PARG | Q86W56 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812542 | 0.83 | TMPRSS4 (0.66) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL4369044 | 0.82 | TMPRSS4 (0.73) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL14885878 | 0.82 | TMPRSS4 (1.00) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| Imd-0354 SCHEMBL29406220 | 0.81 | TMPRSS4 (1.00) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL13812702 | 0.81 | TMPRSS4 (0.94) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| Imd-0354 SCHEMBL129165 | 0.81 | TMPRSS4 (1.00) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL330132 | 0.81 | TMPRSS4 (0.63) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL330059 | 0.79 | TMPRSS4 (0.90) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL2167466 | 0.78 | KCNMA1 (0.54) | TMPRSS4P2RX1KDRPARG | |
| SCHEMBL30211337 | 0.78 | KCNMA1 (0.54) | TMPRSS4P2RX1KDRPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | claimed |
| US-20050187300-A1 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INCORPORATED (US) | 2005-08-25 | — | — | US | claimed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-20050187300-A1 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INCORPORATED (US) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187300-A1 | Compounds, compositions, and methods employing same | HMGCR, APOB, PCSK9 | TMPRSS4 3508/4885P2RX1 3039/4885P2RX4 3360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.