Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Imd-0354. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB known ✓ | O14920 | 1/20 | 1.00 |
| ▸ | TMPRSS4 | Q9NRS4 | 16/20 | 1.00 |
| ▸ | P2RX1 | P51575 | 12/20 | 1.00 |
| ▸ | P2RX4 | Q99571 | 8/20 | 1.00 |
| ▸ | P2RX7 | Q99572 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | CHUK | O15111 | 1/20 | 1.00 |
| ▸ | KDR | P35968 | 1/20 | 1.00 |
| ▸ | FLT3 | P36888 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | MYLK | Q15746 | 1/20 | 1.00 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 1.00 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imd-0354 SCHEMBL29406220 | 1.00 | TMPRSS4 (1.00) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL13812702 | 0.97 | TMPRSS4 (0.94) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL330059 | 0.94 | TMPRSS4 (0.90) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL16707254 | 0.94 | TMPRSS4 (0.88) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL131758 | 0.92 | TMPRSS4 (0.85) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL30100386 | 0.92 | TMPRSS4 (0.85) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL30100462 | 0.92 | TMPRSS4 (0.85) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL14885966 | 0.91 | TMPRSS4 (1.00) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL13189554 | 0.91 | TMPRSS4 (0.83) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL30087037 | 0.90 | TMPRSS4 (0.81) | TMPRSS4P2RX1P2RX4P2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 417 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250082652-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | UNIVERSITÄT ZU KÖLN (DE) | 2025-03-13 | — | — | US | claimed |
| EP-4460301-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | Universität zu Köln (DE) | 2024-11-13 | — | — | EP | claimed |
| EP-3720493-B1 | COMBINATIONS OF RIPK1- AND IKK-INHIBITORS FOR THE PREVENTION OR TREATMENT OF IMMUNE DISEASES | UNIV KOELN (DE) | 2024-07-24 | — | — | EP | claimed |
| CN-117337182-A | Pharmaceutical composition of aquaporin inhibitor and preparation method thereof | 江苏先声药业有限公司 | 2024-01-02 | — | — | CN | claimed |
| US-11801254-B2 | Pharmaceutical compositions and methods of making pharmaceutical compositions comprising 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate | AEROMICS, INC. (US) | 2023-10-31 | — | — | US | claimed |
| US-20230293556-A1 | PHARMACEUTICAL COMPOSITION OF AQUAPORIN INHIBITOR AND PREPARATION METHOD THEREOF | JIANGSU SIMCERE PHARMACEUTICAL CO., LTD. (CN) | 2023-09-21 | — | — | US | claimed |
| WO-2023131576-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | UNIVERSITÄT ZU KÖLN (DE) | 2023-07-13 | — | — | WO | claimed |
| EP-4209213-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | Universität zu Köln (DE) | 2023-07-12 | — | — | EP | claimed |
| EP-4192442-A1 | PHARMACEUTICAL COMPOSITION OF AQUAPORIN INHIBITOR AND PREPARATION METHOD THEREOF | Jiangsu Simcere Pharmaceutical Co., Ltd. (CN) | 2023-06-14 | — | — | EP | claimed |
| US-20220249504-A1 | LONGEVITY SIGNATURES AND THEIR APPLICATIONS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2022-08-11 | — | — | US | claimed |
| US-8263657-B2 | Blocking neurokinins; using a benzene compound containing hydroxy or acetoxy group; antiinflammatory agents | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2012-09-11 | — | — | US | claimed |
| EP-1352650-B1 | INHIBITORS AGAINST THE PRODUCTION AND RELEASE OF INFLAMMATORY CYTOKINES | INST MED MOLECULAR DESIGN INC (JP) | 2012-03-07 | — | — | EP | claimed |
| WO-2012019284-A1 | COMBINATORY CANCER TREATMENT | UNIVERSITE DE MONTREAL (CA) | 2012-02-16 | — | — | WO | claimed |
| US-20090192122-A2 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2009-07-30 | — | — | US | claimed |
| US-20080249071-A1 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2008-10-09 | — | — | US | claimed |
| US-20080090779-A1 | ANTIALLERGIC AGENTS | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2008-04-17 | — | — | US | claimed |
| US-20060122243-A1 | Antiallergic | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2006-06-08 | — | — | US | claimed |
| EP-1514544-A1 | ANTIALLERGIC | Institute of Medicinal Molecular Design, Inc. (JP) | 2005-03-16 | — | — | EP | claimed |
| US-20040259877-A1 | Inhibitors against the production and release of inflammatory cytokines | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2004-12-23 | — | — | US | claimed |
| EP-1352650-A1 | INHIBITORS AGAINST THE PRODUCTION AND RELEASE OF INFLAMMATORY CYTOKINES | Institute of Medicinal Molecular Design, Inc. (JP) | 2003-10-15 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11801254-B2 | Pharmaceutical compositions and methods of making pharmaceutical compositions comprising 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate | PLCG2, DCTPP1, PLCG1 | IKBKB 4164/4885TMPRSS4 1479/4885P2RX1 790/4885 |
| US-20080090779-A1 | ANTIALLERGIC AGENTS | NAT1, EPX, HRH2 | IKBKB 626/4885TMPRSS4 4322/4885P2RX1 2484/4885 |
| US-20060122243-A1 | Antiallergic | EPX, NAT1, HNMT | IKBKB 645/4885TMPRSS4 4304/4885P2RX1 2927/4885 |
| US-20090192122-A2 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | IL1B, NFKBIA, IL1A | IKBKB 9/4885TMPRSS4 1647/4885P2RX1 1538/4885 |
| US-20080249071-A1 | INFLAMMATORY CYTOKINE RELEASE INHIBITOR | IL1B, NFKBIA, IL1A | IKBKB 9/4885TMPRSS4 1647/4885P2RX1 1538/4885 |
| US-20230293556-A1 | PHARMACEUTICAL COMPOSITION OF AQUAPORIN INHIBITOR AND PREPARATION METHOD THEREOF | AQP1, AQP4, AQP3 | IKBKB 1654/4885TMPRSS4 2849/4885P2RX1 588/4885 |
| US-20220249504-A1 | LONGEVITY SIGNATURES AND THEIR APPLICATIONS | GLA, LIMS1, GLB1 | IKBKB 2782/4885TMPRSS4 4552/4885P2RX1 4382/4885 |
| US-20040259877-A1 | Inhibitors against the production and release of inflammatory cytokines | NFKBIA, IL1B, IKBKB | IKBKB 3/4885TMPRSS4 3292/4885P2RX1 2316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.