Sugi Predict

Sugi Predict / Compounds / SCHEMBL4367063

SCHEMBL4367063

SCHEMBL4367063

O=C(O)c1cc(C#Cc2ccccc2)cc(C#Cc2ccccc2)c1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ APP P05067 1/20 0.52
▸ HNF4A P41235 1/20 0.52
▸ AKR1C2 P52895 1/20 0.51
▸ AKR1C1 Q04828 1/20 0.51
▸ DAO P14920 1/20 0.48
▸ TSHR P16473 1/20 0.48
▸ NAPRT Q6XQN6 1/20 0.48
▸ FFAR1 O14842 5/20 0.47
▸ MAPT P10636 1/20 0.46
▸ FFAR4 Q5NUL3 2/20 0.46
▸ PTPN11 Q06124 1/20 0.44
▸ NPC1 O15118 1/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ RARB P10826 1/20 0.44
▸ RARG P13631 1/20 0.44
▸ VCP P55072 1/20 0.43
▸ SLC7A11 Q9UPY5 1/20 0.43
▸ PKM P14618 1/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2707734 0.96 APP (0.52) APPHNF4AAKR1C2AKR1C1DAO
Hydrochloric Acid SCHEMBL2709682 0.94 AKR1C2 (0.50) APPHNF4AAKR1C2AKR1C1DAO
Hydrochloric Acid SCHEMBL2746715 0.94 AKR1C2 (0.50) APPHNF4AAKR1C2AKR1C1DAO
SCHEMBL2746660 0.94 AKR1C2 (0.50) APPHNF4AAKR1C2AKR1C1DAO
SCHEMBL26162806 0.91 MRGPRX4 (0.53) APPHNF4AAKR1C2AKR1C1DAO
SCHEMBL7191159 0.91 AKR1C2 (0.49) APPHNF4AAKR1C2AKR1C1DAO
SCHEMBL5669815 0.90 DHODH (0.49) APPHNF4AAKR1C2AKR1C1DAO
SCHEMBL29908913 0.89 HNF4A (0.46) HNF4AAKR1C2AKR1C1DAOTSHR
SCHEMBL16103102 0.89 RARB (0.56) APPHNF4AAKR1C2AKR1C1DAO
SCHEMBL18604545 0.89 RARB (0.50) APPHNF4AAKR1C2AKR1C1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10894848-B2 Polyarylene resins ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2021-01-19 — — US disclosed
EP-3336125-A1 POLYARYLENE RESIN COMPOSITIONS Rohm and Haas Electronic Materials LLC (US) 2018-06-20 — — EP disclosed
EP-3336126-A1 POLYARYLENE RESINS Rohm and Haas Electronic Materials LLC (US) 2018-06-20 — — EP disclosed
US-20180162968-A1 POLYARYLENE RESINS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2018-06-14 — — US disclosed
US-20180162967-A1 POLYARYLENE RESIN COMPOSITIONS ROHM & HAAS ELECT MAT (US) 2018-06-14 — — US disclosed
EP-3248997-A1 POLYARYLENE MATERIALS Rohm and Haas Electronic Materials LLC (US) 2017-11-29 — — EP disclosed
US-20170009006-A1 POLYARYLENE MATERIALS ROHM AND HAAS ELECTRONIC MATERIALS LLC 2017-01-12 — — US disclosed
EP-3115392-A1 POLYARYLENE MATERIALS Rohm and Haas Electronic Materials LLC (US) 2017-01-11 — — EP disclosed
US-20090247701-A1 COMPOSITION FOR FORMING AN INSULATING FILM FUJIFILM CORPORATION (JP) 2009-10-01 — — US disclosed
US-7109249-B2 Composition containing a cross-linkable matrix precursor and a poragen, and porous matrix prepared therefrom DOW GLOBAL TECHNOLOGIES INC. (US) 2006-09-19 — — US disclosed
EP-1141128-B1 A COMPOSITION CONTAINING A CROSS-LINKABLE MATRIX PRECURSOR AND A PORAGEN, AND A POROUS MATRIX PREPARED THEREFROM DOW GLOBAL TECHNOLOGIES INC (US) 2006-04-12 — — EP disclosed
US-6887910-B2 Composition containing a cross-linkable matrix precursor and a poragen, and a porous matrix prepared therefrom DOW GLOBAL TECHNOLOGIES INC. (US) 2005-05-03 — — US disclosed
US-20050014855-A1 Composition containing a cross-linkable matrix precursor and a poragen, and a porous matrix prepared therefrom BRUZA KENNETH J (US) 2005-01-20 — — US disclosed
US-6653358-B2 Electronics; integrated circuits; containing benzocyclobutene polymer DOW GLOBAL TECHNOLOGIES INC. 2003-11-25 — — US disclosed
US-6630520-B1 Matrix precursor comprises a material selected from cyclopentadienone and acetylene functional compounds, at least some of which have three or more reactive functional groups; partially polymerized reaction products and perfluoroethylenes DOW GLOBAL TECHNOLOGIES INC. 2003-10-07 — — US disclosed
US-20030092785-A1 Composition containing a cross-linkable matrix precursor and a poragen, and a porous matrix prepared therefrom BRUZA KENNETH J (US) 2003-05-15 — — US disclosed
US-20030083392-A1 Composition containing a cross-linkable matrix precursor and a poragen, and a porous matrix prepared therefrom BRUZA KENNETH J (US) 2003-05-01 — — US disclosed
EP-1141128-A1 A COMPOSITION CONTAINING A CROSS-LINKABLE MATRIX PRECURSOR AND A PORAGEN, AND A POROUS MATRIX PREPARED THEREFROM THE DOW CHEMICAL COMPANY (US) 2001-10-10 — — EP disclosed
WO-2000031183-A1 A COMPOSITION CONTAINING A CROSS-LINKABLE MATRIX PRECURSOR AND A PORAGEN, AND A POROUS MATRIX PREPARED THEREFROM THE DOW CHEMICAL COMPANY (US) 2000-06-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10894848-B2 Polyarylene resins PIN1, HSD17B12, PCBP1 APP 600/4885HNF4A 2968/4885AKR1C2 391/4885
US-20180162967-A1 POLYARYLENE RESIN COMPOSITIONS PARG, PUF60, PCBP1 APP 289/4885HNF4A 4399/4885AKR1C2 1969/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.