Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of 2-Pyrrolidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Pyrrolidone SCHEMBL1048019 | 1.00 | OR51E2 (0.94) | — | |
| 2-Pyrrolidone SCHEMBL511486 | 1.00 | — | — | |
| 2-Pyrrolidone SCHEMBL28877688 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL28933712 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL9441874 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL27827832 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL4299593 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL9304498 | 0.97 | OR51E2 (1.00) | — | |
| 2-Pyrrolidone SCHEMBL2389 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL2167448 | 0.97 | OR51E2 (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4698516-A1 | PYRROLIDINONE UREA FPR2 AGONISTS | Bristol-Myers Squibb Company (US) | 2026-02-25 | — | — | EP | disclosed |
| US-20240409533-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-12-12 | — | — | US | disclosed |
| CN-113874074-B | HMOX1 inducers | 米托布里奇公司 | 2024-11-01 | — | — | CN | disclosed |
| WO-2024220453-A1 | PYRROLIDINONE UREA FPR2 AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-10-24 | — | — | WO | disclosed |
| US-12071433-B2 | HMOX1 inducers | Astellas Engineered Small Molecules US, Incorporated (US) | 2024-08-27 | — | — | US | disclosed |
| US-20240051952-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-02-15 | — | — | US | disclosed |
| US-20220177460-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2022-06-09 | — | — | US | disclosed |
| EP-3952990-A1 | HMOX1 INDUCERS | Mitobridge, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| CN-113874074-A | HMOX1 inducers | 米托布里奇公司 | 2021-12-31 | — | — | CN | disclosed |
| WO-2020210339-A1 | HMOX1 INDUCERS | MITOBRIDGE, INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| US-4493836-A | HYPOTENSIVE, ANTISEROTONINE AGENTS, DOPAMINE ANTAGONIST | Uclaf, Roussel (FR) | 1985-01-15 | — | — | US | disclosed |
| EP-0102540-A2 | Beta-triazolyl ketals, process for their preparation and fungicides containing them | BASF Aktiengesellschaft (DE) | 1984-03-14 | — | — | EP | disclosed |
| EP-0102543-A2 | Dioxanylazol derivatives, fungicides containing them and their use as fungicides | BASF Aktiengesellschaft (DE) | 1984-03-14 | — | — | EP | disclosed |
| US-4385925-A | 1,3-Dioxan-5-yl-alkyltriazoles, their preparation, their use for regulating plant growth, and regulators containing these compounds | BASF AKTIENGESELLSCHAFT (DE) | 1983-05-31 | — | — | US | disclosed |
| US-4368066-A | 1,3-Dioxan-5-yl-alkenyltriazoles, their preparation, their uses in regulating plant growth, and regulators containing these compounds | BASF AKTIENGESELLSCHAFT (DE) | 1983-01-11 | — | — | US | disclosed |
| EP-0062236-A2 | Use of triazole derivatives for combating fungi | BASF Aktiengesellschaft (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4318910-A | Indolobenzoxazines | ROUSSEL UCLAF (FR) | 1982-03-09 | — | — | US | disclosed |
| EP-0044407-A2 | 1,3-Dioxan-5-yl-alkyl triazoles, their preparation and their use as plant growth regulators | BASF Aktiengesellschaft (DE) | 1982-01-27 | — | — | EP | disclosed |
| EP-0043923-A2 | 1,3-Dioxan-5-yl-alkenyl triazoles, their preparation and their use as plant growth regulators | BASF Aktiengesellschaft (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4041064-A | PROSTAGLANDINS; ANTISPASMODICS, ISOTONICS, ANTIASTHMATICS, ANTIULCER AND ANTISECRETORY AGENTS | CARLO-ERBA S.P.A. (IT) | 1977-08-09 | — | — | US | disclosed |