Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of 2-Pyrrolidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.94 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.78 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.30 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Pyrrolidone SCHEMBL4367304 | 1.00 | — | — | |
| 2-Pyrrolidone SCHEMBL511486 | 1.00 | — | — | |
| 2-Pyrrolidone SCHEMBL28877688 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL28933712 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL9441874 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL27827832 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL4299593 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL9304498 | 0.97 | OR51E2 (1.00) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL2389 | 0.97 | — | — | |
| 2-Pyrrolidone SCHEMBL2167448 | 0.97 | OR51E2 (1.00) | OR51E2CRBNFKBP5KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120004697-A | Preparation method of OrgVO material and application of OrgVO material as secondary battery anode material | 同济大学 | 2025-05-16 | — | — | CN | claimed |
| US-20250195502-A1 | APPLICATION OF TETRACYCLIC COMPOUND IN TREATMENT OF TUMORS | SHANGHAI SHIJIANG BIOTECHNOLOGY CO., LTD (CN) | 2025-06-19 | — | — | US | disclosed |
| CN-120004697-A | Preparation method of OrgVO material and application of OrgVO material as secondary battery anode material | 同济大学 | 2025-05-16 | — | — | CN | disclosed |
| WO-2024114765-A9 | BENZOPYRONE COMPOUNDS AS WELL AS PREPARATION METHOD THEREFOR AND USE THEREOF | 成都地奥九泓制药厂 | 2025-04-03 | — | — | WO | disclosed |
| EP-4491182-A1 | APPLICATION OF TETRACYCLIC COMPOUND IN TREATMENT OF TUMORS | Shanghai Shijiang Biotechnology Co., Ltd (CN) | 2025-01-15 | — | — | EP | disclosed |
| WO-2024114765-A1 | BENZOPYRONE COMPOUNDS AS WELL AS PREPARATION METHOD THEREFOR AND USE THEREOF | 成都地奥九泓制药厂 | 2024-06-06 | — | — | WO | disclosed |
| CN-111954685-B | Process for producing 4-methyl-1-pentene polymer particles and 4-methyl-1-pentene resin | 三井化学株式会社 | 2023-08-08 | — | — | CN | disclosed |
| CN-111954685-A | 4-methyl-1-pentene polymer particles and method for producing 4-methyl-1-pentene resin | 三井化学株式会社 | 2020-11-17 | — | — | CN | disclosed |
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |
| US-7906522-B2 | 2-aminoquinazoline derivatives | KYOWA HAKKO KIRIN CO., LTD (JP) | 2011-03-15 | — | — | US | disclosed |
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
| EP-2269993-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-01-05 | — | — | EP | disclosed |
| US-20090137583-A1 | 2-AMINOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-28 | — | — | US | disclosed |
| EP-1878727-A1 | 2-AMINOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-01-16 | — | — | EP | disclosed |
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | KYOWA HAKKO KOGYO CO.,LTD. (JP) | 2007-09-27 | — | — | US | disclosed |
| EP-1726584-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | AGTR2, ABL1, AGTR1 | OR51E2 3344/4885CRBN 2435/4885FKBP5 3139/4885 |
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | H1-2, H1-3, H1-0 | OR51E2 3271/4885CRBN 3374/4885FKBP5 4138/4885 |
| US-20090137583-A1 | 2-AMINOQUINAZOLINE DERIVATIVES | SLC7A1, SLC38A7, PRMT7 | OR51E2 2236/4885CRBN 122/4885FKBP5 4052/4885 |
| US-20250195502-A1 | APPLICATION OF TETRACYCLIC COMPOUND IN TREATMENT OF TUMORS | NNMT, UHRF1, TET1 | OR51E2 1488/4885CRBN 3112/4885FKBP5 2427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.