Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9586141 | 0.84 | MAPT (0.51) | MAPTTSHRPOLBKDM4ECDC7 | |
| SCHEMBL406826 | 0.83 | KCNMA1 (0.48) | MAPTTSHRNPC1SMN1; SMN2POLB | |
| SCHEMBL9585857 | 0.83 | TARBP2 (0.56) | MAPTTSHRNPC1SMN1; SMN2POLB | |
| SCHEMBL405091 | 0.81 | KCNMA1 (0.46) | MAPTSMN1; SMN2TARBP2NPSR1GABRA2 | |
| SCHEMBL9586903 | 0.81 | L3MBTL1 (0.50) | MAPTTARBP2GABRA2GABRB2ALDH1A1 | |
| SCHEMBL4372570 | 0.79 | ALPL (0.46) | TSHRNPC1SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL17261736 | 0.79 | MAPT (0.51) | MAPTTSHRNPC1SMN1; SMN2POLB | |
| SCHEMBL955251 | 0.78 | MAPT (0.52) | MAPTTSHRNPC1SMN1; SMN2POLB | |
| SCHEMBL17261761 | 0.77 | MAPT (0.49) | MAPTTSHRNPC1SMN1; SMN2POLB | |
| SCHEMBL2305862 | 0.76 | ELANE (0.44) | MAPTTSHRNPC1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |