Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375499 | 0.92 | CNR1 (0.49) | CNR1TSHRCNR2CRHR1FAAH | |
| SCHEMBL4368598 | 0.91 | CNR2 (0.42) | CNR1TSHRCNR2 | |
| SCHEMBL4374742 | 0.91 | TSHR (0.42) | CNR1TSHRCNR2ALDH1A1LMNA | |
| SCHEMBL4380007 | 0.90 | CNR1 (0.60) | CNR1TSHRCNR2CRHR1KDM4E | |
| SCHEMBL4380450 | 0.89 | CNR1 (0.43) | CNR1TSHRCNR2CRHR1ALDH1A1 | |
| SCHEMBL4369770 | 0.88 | CNR1 (0.48) | CNR1CRHR1FAAHMRGPRX4 | |
| SCHEMBL4371325 | 0.86 | CNR1 (0.65) | CNR1CNR2CRHR1FAAH | |
| SCHEMBL4373433 | 0.85 | ALDH1A1 (0.40) | TSHRCNR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4373566 | 0.83 | CNR1 (0.58) | CNR1TSHRCNR2CRHR1 | |
| SCHEMBL4376045 | 0.83 | TSHR (0.42) | CNR1TSHRCNR2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749002-B1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | claimed |