Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375462 | 0.91 | TSHR (0.39) | ALDH1A1SMN1; SMN2TSHRKDM4EGLA | |
| SCHEMBL4372670 | 0.89 | CNR1 (0.42) | ALDH1A1SMN1; SMN2TSHRKDM4EGLA | |
| SCHEMBL4368598 | 0.86 | CNR2 (0.42) | TSHRCNR2 | |
| SCHEMBL4374742 | 0.86 | TSHR (0.42) | ALDH1A1LMNASMN1; SMN2FAAHTSHR | |
| SCHEMBL4368758 | 0.85 | CNR1 (0.51) | ALDH1A1LMNASMN1; SMN2FAAHTSHR | |
| SCHEMBL4383359 | 0.85 | RORC (0.46) | ALDH1A1LMNASMN1; SMN2TSHRKDM4E | |
| SCHEMBL4379995 | 0.84 | CNR2 (0.39) | TSHRCNR2KMT2AGRIN1GRIN2B | |
| SCHEMBL4380421 | 0.84 | CNR2 (0.39) | TSHRCNR2KMT2AGRIN1GRIN2B | |
| SCHEMBL4373529 | 0.82 | CNR2 (0.39) | TSHRCNR2KMT2AGRIN1GRIN2B | |
| SCHEMBL4380524 | 0.81 | EPHX1 (0.41) | ALDH1A1LMNASMN1; SMN2FAAHTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749002-B1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | claimed |