Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.55 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | XDH | P47989 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4360657 | 0.97 | PLA2G4A (0.68) | PLA2G4AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1144832 | 0.94 | KDM4E (0.65) | PLA2G4AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6469163 | 0.89 | KDM4E (0.60) | PLA2G4AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL13174431 | 0.89 | KDM4E (0.62) | PLA2G4AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL24076666 | 0.89 | PLA2G4A (0.55) | PLA2G4AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2767179 | 0.89 | KDM4E (0.65) | PLA2G4AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4371734 | 0.88 | PDGFRB (0.71) | PLA2G4AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4816031 | 0.87 | KDM4E (0.64) | PLA2G4AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3033147 | 0.87 | KDM4E (0.67) | PLA2G4AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3017316 | 0.87 | KDM4E (0.60) | PLA2G4AKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063495-A2 | SUBSTITUTED INDOLE AND ITS DERIVATIVES AS CANNABINOID MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2009-05-22 | — | — | WO | claimed |
| WO-2009063495-A2 | SUBSTITUTED INDOLE AND ITS DERIVATIVES AS CANNABINOID MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2009-05-22 | — | — | WO | disclosed |
| US-20050026987-A1 | CBI analogues of the duocarmycins and CC-1065 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-03 | — | — | US | disclosed |
| WO-2004101767-A2 | CBI ANALOGUES OF THE DUOCARMYCINS AND CC-1065 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026987-A1 | CBI analogues of the duocarmycins and CC-1065 | CCNI, SP1, DCK | PLA2G4A 2480/4885KDM4E 1508/4885ALDH1A1 4597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.