Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3017321 | 0.94 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL4369016 | 0.87 | PLA2G4A (0.67) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL13174431 | 0.84 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL4360657 | 0.84 | PLA2G4A (0.68) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL1144832 | 0.84 | KDM4E (0.65) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL2767179 | 0.84 | KDM4E (0.65) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL4816031 | 0.83 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL3033147 | 0.82 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL9816433 | 0.81 | KDM4E (0.73) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL4371734 | 0.81 | PDGFRB (0.71) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | KDM4E 1070/4885ALDH1A1 348/4885HPGD 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.