Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.65 |
| ▸ | ITGAV | P06756 | 18/20 | 0.65 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4363508 | 1.00 | ITGB3 (0.65) | ITGB3ITGAVITGA2BITGB5F2R | |
| SCHEMBL4372884 | 1.00 | ITGB3 (0.65) | ITGB3ITGAVITGA2BITGB5F2R | |
| SCHEMBL4045463 | 0.88 | ITGB3 (0.50) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL4368878 | 0.86 | ITGAV (0.47) | ITGB3ITGAVITGA2B | |
| SCHEMBL7589610 | 0.85 | ITGAV (0.47) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL7591361 | 0.85 | ITGAV (0.47) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL4382525 | 0.85 | ITGB3 (0.46) | ITGB3ITGAVITGA2B | |
| SCHEMBL4050199 | 0.84 | ITGB3 (0.51) | ITGB3ITGAV | |
| SCHEMBL4374458 | 0.84 | ITGB3 (0.45) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL4366546 | 0.84 | ITGAV (0.45) | ITGB3ITGAVITGA2BITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047425-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-04-22 | — | — | EP | disclosed |
| EP-1047425-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999030709-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |