Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 14/20 | 0.45 |
| ▸ | ITGAV | P06756 | 14/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382525 | 0.86 | ITGB3 (0.46) | ITGB3ITGAVITGA2BLMNA | |
| SCHEMBL7590648 | 0.85 | ITGAV (0.43) | ITGB3ITGAVHDAC3HDAC4HDAC1 | |
| SCHEMBL7590552 | 0.85 | ITGAV (0.43) | ITGB3ITGAVHDAC3HDAC4HDAC1 | |
| SCHEMBL7557082 | 0.85 | ITGAV (0.43) | ITGB3ITGAVHDAC3HDAC4HDAC1 | |
| SCHEMBL4363508 | 0.84 | ITGB3 (0.65) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL4372884 | 0.84 | ITGB3 (0.65) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL4370537 | 0.84 | ITGB3 (0.65) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL4048448 | 0.80 | ITGB3 (0.41) | ITGB3ITGAV | |
| SCHEMBL4045463 | 0.80 | ITGB3 (0.50) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL4053563 | 0.80 | ITGB3 (0.50) | ITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047425-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-04-22 | — | — | EP | claimed |
| EP-1047425-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-11-02 | — | — | EP | claimed |
| WO-1999030709-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | claimed |
| EP-1047425-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-04-22 | — | — | EP | disclosed |
| EP-1047425-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999030709-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |