Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30062543 | 1.00 | ALDH1A1 (0.46) | ALDH1A1POLBSMN1; SMN2PLAUKDM4E | |
| SCHEMBL9255319 | 0.83 | TSHR (0.32) | ALDH1A1HTTGAA | |
| SCHEMBL6371294 | 0.81 | ALOX5AP (0.39) | ALDH1A1POLBL3MBTL1LMNARAB9A | |
| SCHEMBL120994 | 0.80 | ALDH1A1 (0.56) | ALDH1A1POLBSMN1; SMN2PLAUKDM4E | |
| SCHEMBL29414916 | 0.80 | ALDH1A1 (0.56) | ALDH1A1POLBSMN1; SMN2PLAUKDM4E | |
| SCHEMBL30144074 | 0.78 | AGBL2 (0.47) | ALDH1A1POLBSMN1; SMN2PLAUKDM4E | |
| SCHEMBL8408164 | 0.78 | PIK3CD (0.50) | ALDH1A1POLBSMN1; SMN2PLAUKDM4E | |
| SCHEMBL753475 | 0.78 | AGBL2 (0.47) | ALDH1A1POLBSMN1; SMN2PLAUKDM4E | |
| SCHEMBL31310688 | 0.78 | PIK3CD (0.50) | ALDH1A1POLBSMN1; SMN2PLAUKDM4E | |
| SCHEMBL609041 | 0.77 | ALDH1A1 (0.40) | ALDH1A1POLBSMN1; SMN2PLAUKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059166-A1 | PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2025-02-20 | — | — | US | disclosed |
| US-12226405-B2 | Compounds and compositions for inhibiting the activity of HIF2-alpha and their methods of use | NOVARTIS AG (CH) | 2025-02-18 | — | — | US | disclosed |
| US-20240351997-A1 | NOVEL PARP7 INHIBITOR AND USE THEREOF | SHANGHAI QILU PHARMACEUTICAL RESEARCH AND DEVELOPMENT CENTRE LTD. (CN) | 2024-10-24 | — | — | US | disclosed |
| EP-4378938-A1 | NOVEL PARP7 INHIBITOR AND USE THEREOF | Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. (CN) | 2024-06-05 | — | — | EP | disclosed |
| EP-4143187-B1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-ALPHA AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2024-05-08 | — | — | EP | disclosed |
| CN-117642393-A | Novel PARP7 inhibitor and application thereof | 上海齐鲁制药研究中心有限公司 | 2024-03-01 | — | — | CN | disclosed |
| EP-4143187-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-ALPHA AND THEIR METHODS OF USE | Novartis AG (CH) | 2023-03-08 | — | — | EP | disclosed |
| WO-2023006013-A1 | NOVEL PARP7 INHIBITOR AND USE THEREOF | 上海齐鲁制药研究中心有限公司 | 2023-02-02 | — | — | WO | disclosed |
| US-20220401422-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-alpha AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2022-12-22 | — | — | US | disclosed |
| CN-115485275-A | Compounds and compositions that inhibit HIF 2-alpha activity and methods of use thereof | 诺华股份有限公司 | 2022-12-16 | — | — | CN | disclosed |
| EP-0178260-A2 | Process for the preparation of fluorinated pyridine derivatives | CIBA-GEIGY AG (CH) | 1986-04-16 | — | — | EP | disclosed |
| US-4567274-A | TRICHLOROMETHYL OR DICHLORFLUOROMETHLPICOLINE | THE DOW CHEMICAL COMPANY (US) | 1986-01-28 | — | — | US | disclosed |
| US-4565568-A | Pyridyl(oxy/thio)phenoxy compounds, herbicidal compositions and methods | THE DOW CHEMICAL COMPANY (US) | 1986-01-21 | — | — | US | disclosed |
| US-4480102-A | 2,3-Difluoro-5-(trifluoromethyl)pyridine and methods of making and using the same | THE DOW CHEMICAL COMPANY (US) | 1984-10-30 | — | — | US | disclosed |
| EP-0104715-A2 | 2,3-Difluoro-5-(trifluoromethyl)pyridine and method of making and using the same | THE DOW CHEMICAL COMPANY (US) | 1984-04-04 | — | — | EP | disclosed |
| EP-0097460-A1 | Pyridyl(oxy/thio)phenoxy compounds, herbicidal compositions and methods | THE DOW CHEMICAL COMPANY (US) | 1984-01-04 | — | — | EP | disclosed |
| US-4393212-A | ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1983-07-12 | — | — | US | disclosed |
| US-4294969-A | COUPLING N-BROMOSUCCINIMIDE AND A 2-BROMOPYRIDINE | MERCK & CO., INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4279913-A | ANTIARRYTHMIA, HYPOTENSIVE | MERCK & CO., INC. (US) | 1981-07-21 | — | — | US | disclosed |
| EP-0003278-A1 | Polysubstituted-2-(3-loweralkylamino-2-R0-propoxy)pyridines, process for preparing the same, and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1979-08-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12226405-B2 | Compounds and compositions for inhibiting the activity of HIF2-alpha and their methods of use | HIF1AN, HIF1A, EGLN2 | ALDH1A1 450/4885POLB 945/4885SMN1; SMN2 1776/4885 |
| US-20220401422-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-alpha AND THEIR METHODS OF USE | HIF1AN, HIF1A, EGLN2 | ALDH1A1 450/4885POLB 945/4885SMN1; SMN2 1776/4885 |
| US-20250059166-A1 | PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN | QPCT, QPCTL, GLUL | ALDH1A1 3857/4885POLB 844/4885SMN1; SMN2 4484/4885 |
| US-20240351997-A1 | NOVEL PARP7 INHIBITOR AND USE THEREOF | PARP6, PARP4, PARP3 | ALDH1A1 549/4885POLB 197/4885SMN1; SMN2 3311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.