Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 4/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.36 |
| ▸ | FLT4 | P35916 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2999364 | 0.90 | ALDH1A1 (0.39) | CYP1A1CYP1B1MEN1KMT2AALDH1A1 | |
| SCHEMBL30550463 | 0.90 | ALDH1A1 (0.39) | CYP1A1CYP1B1MEN1KMT2AALDH1A1 | |
| SCHEMBL23731386 | 0.86 | EGFR (0.40) | CYP1A1CYP1B1ALDH1A1EGFRNPC1 | |
| SCHEMBL3002812 | 0.86 | BCL2L1 (0.38) | PTGS2ALOX5CYP3A4KDM4EGAA | |
| SCHEMBL22618607 | 0.82 | MAOA (0.37) | PTGS2ALOX5CYP3A4KDM4EGAA | |
| SCHEMBL29383596 | 0.82 | MAOA (0.37) | PTGS2ALOX5CYP3A4KDM4EGAA | |
| SCHEMBL21357843 | 0.78 | CYP3A4 (0.47) | PTGS2ALOX5KITPDGFRAFLT4 | |
| SCHEMBL30777410 | 0.78 | CYP3A4 (0.47) | PTGS2ALOX5KITPDGFRAFLT4 | |
| SCHEMBL21584122 | 0.74 | PTGS2 (0.34) | PTGS2ALOX5ESR1BACE1 | |
| SCHEMBL2999085 | 0.74 | PGR (0.47) | CYP3A4TTRKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070921-A1 | Indolylmaleimide derivatives as protein kinase c inhibitors | Novartis Ag (CH) | 2009-06-17 | — | — | EP | disclosed |