Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 13/20 | 0.37 |
| ▸ | MMP1 | P03956 | 11/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373799 | 0.90 | MMP2 (0.38) | MMP2MMP9MMP13MMP1SCN9A | |
| SCHEMBL4372216 | 0.88 | MMP2 (0.37) | MMP2MMP9MMP13MMP1SCN9A | |
| SCHEMBL3869082 | 0.88 | MMP2 (0.42) | MMP2MMP9MMP13MMP1SCN9A | |
| SCHEMBL4371577 | 0.83 | MMP2 (0.37) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL4374349 | 0.83 | MMP2 (0.46) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL4374166 | 0.82 | MMP2 (0.45) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL4374481 | 0.82 | MMP2 (0.50) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL4371607 | 0.81 | MMP2 (0.44) | MMP2MMP9MMP13MMP3MMP7 | |
| SCHEMBL1802607 | 0.80 | MMP2 (0.52) | MMP2MMP9MMP13MMP1SCN9A | |
| SCHEMBL4369114 | 0.77 | MMP2 (0.40) | MMP2MMP9MMP13MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |