Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.34 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371607 | 0.93 | MMP2 (0.44) | MMP2MMP9ITGB3ITGA2BMMP13 | |
| SCHEMBL4373799 | 0.92 | MMP2 (0.38) | MMP2MMP9ITGB3ITGA2BSCN9A | |
| SCHEMBL4372240 | 0.88 | MMP2 (0.41) | MMP2MMP9SCN9AMMP1MMP13 | |
| SCHEMBL4374166 | 0.85 | MMP2 (0.45) | MMP2MMP9ITGB3ITGA2BADAMTS4 | |
| SCHEMBL4369622 | 0.82 | MMP2 (0.35) | MMP2MMP9ITGB3ITGA2BSCN9A | |
| SCHEMBL4369114 | 0.78 | MMP2 (0.40) | MMP2MMP9MMP1ALDH1A1MMP13 | |
| SCHEMBL3869082 | 0.78 | MMP2 (0.42) | MMP2MMP9SCN9AMMP1ADAM17 | |
| SCHEMBL4371577 | 0.78 | MMP2 (0.37) | MMP2MMP9MMP1MMP13MMP8 | |
| SCHEMBL4374349 | 0.78 | MMP2 (0.46) | MMP2MMP9ITGB3ITGA2BADAMTS4 | |
| SCHEMBL1800964 | 0.78 | ADAM17 (0.47) | MMP2MMP9ADAMTS4MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |