Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.50 |
| ▸ | MMP9 | P14780 | 9/20 | 0.50 |
| ▸ | MMP13 | P45452 | 8/20 | 0.44 |
| ▸ | MMP3 | P08254 | 5/20 | 0.44 |
| ▸ | MMP14 | P50281 | 5/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374349 | 0.87 | MMP2 (0.46) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL4374166 | 0.86 | MMP2 (0.45) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL4371607 | 0.84 | MMP2 (0.44) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL4377599 | 0.83 | MMP2 (0.46) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL4372240 | 0.82 | MMP2 (0.41) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL1800122 | 0.80 | MMP2 (0.65) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL4369114 | 0.80 | MMP2 (0.40) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL4381075 | 0.79 | MMP2 (0.39) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL4373799 | 0.79 | MMP2 (0.38) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL4372216 | 0.77 | MMP2 (0.37) | MMP2MMP9MMP13ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |