Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.38 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | HPN | P05981 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374166 | 0.93 | MMP2 (0.45) | MMP2MMP9MMP8MMP12MMP14 | |
| SCHEMBL4372216 | 0.92 | MMP2 (0.37) | MMP2MMP9SCN9AMMP8ITGB3 | |
| SCHEMBL4372240 | 0.90 | MMP2 (0.41) | MMP2MMP9SCN9AMMP8MMP12 | |
| SCHEMBL4371607 | 0.85 | MMP2 (0.44) | MMP2MMP9MMP8MMP12MMP14 | |
| SCHEMBL4374530 | 0.81 | MMP2 (0.36) | MMP2MMP9MMP8MMP12MMP14 | |
| SCHEMBL4369114 | 0.80 | MMP2 (0.40) | MMP2MMP9MMP12MMP14CA1 | |
| SCHEMBL3869082 | 0.80 | MMP2 (0.42) | MMP2MMP9SCN9AMMP8MMP12 | |
| SCHEMBL4371577 | 0.79 | MMP2 (0.37) | MMP2MMP9MMP8MMP12MMP14 | |
| SCHEMBL4374349 | 0.79 | MMP2 (0.46) | MMP2MMP9MMP8MMP12MMP14 | |
| SCHEMBL4374481 | 0.79 | MMP2 (0.50) | MMP2MMP9MMP12MMP14ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |