SCHEMBL437230

SCHEMBL437230

O=[N+]([O-])c1cccc2nc3ccccc3cc12

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.69
MEN1 O00255 6/20 0.69
RAB9A P51151 4/20 0.69
ALDH1A1 P00352 6/20 0.59
MAPT P10636 5/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
MAPK1 P28482 1/20 0.53
TDP1 Q9NUW8 1/20 0.52
POLB P06746 3/20 0.51
GLA P06280 3/20 0.51
HPGD P15428 2/20 0.51
NPC1 O15118 2/20 0.51
KDM4E B2RXH2 2/20 0.51
GAA P10253 2/20 0.51
LMNA P02545 1/20 0.51
PTBP1 P26599 1/20 0.51
RCE1 Q9Y256 1/20 0.51
HTT P42858 1/20 0.47
ATM Q13315 1/20 0.47
ACHE P22303 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30307374 1.00 KMT2A (0.69) KMT2AMEN1RAB9AALDH1A1MAPT
Hydrochloric Acid SCHEMBL7461797 0.98 KMT2A (0.68) KMT2AMEN1RAB9AALDH1A1MAPT
Hydrochloric Acid SCHEMBL18095065 0.98 KMT2A (0.68) KMT2AMEN1RAB9AALDH1A1MAPT
Acridine SCHEMBL28057414 0.98 KMT2A (0.68) KMT2AMEN1RAB9AALDH1A1MAPT
Ammonia Solution, Strong SCHEMBL27885667 0.98 KMT2A (0.68) KMT2AMEN1RAB9AALDH1A1MAPT
Acridine SCHEMBL27545385 0.85 RAB9A (0.63) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL153507 0.82 KMT2A (0.60) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL11061940 0.80 ALDH1A1 (0.50) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL9735773 0.79 ALDH1A1 (0.69) KMT2AMEN1RAB9AALDH1A1MAPT
SCHEMBL11333926 0.79 KMT2A (0.64) KMT2AMEN1RAB9AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 774 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119894893-A Sulfone substituted pyrido [3,4-D ] pyrimidine derivatives for the treatment of cancer 拜耳公司 2025-04-25 CN claimed
CN-119838022-A Amatoxin conjugates containing branched linkers 杭州多禧生物科技有限公司 2025-04-18 CN claimed
CN-118557747-A Conjugates of cell binding molecules and camptothecin analogs 杭州多禧生物科技有限公司 2024-08-30 CN claimed
CN-118451106-A Combination therapy of Claudin 18.2 antagonists and PD-1/PD-L1 axis inhibitors 苏州创胜医药集团有限公司 2024-08-06 CN claimed
CN-118434765-A BCMA monoclonal antibodies and antibody-drug conjugates 杭州多禧生物科技有限公司 2024-08-02 CN claimed
CN-118215676-A Specific conjugation of antibody drug conjugates 杭州多禧生物科技有限公司 2024-06-18 CN claimed
CN-117500507-A Phosphorus derivatives as novel SOS1 inhibitors 拜耳公司 2024-02-02 CN claimed
CN-117244076-A Conjugates comprising self-degrading groups and methods related thereto 乐高化学生物科学股份有限公司 2023-12-19 CN claimed
CN-116999571-A Antibody-drug conjugates comprising anti-B7-H3 antibodies 尹图赛利有限公司 2023-11-07 CN claimed
CN-116806157-A Linker-payload and conjugates thereof 芬兰吉利科斯有限公司 2023-09-26 CN claimed
US-20050043233-A1 Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-02-24 US claimed
US-20040245105-A1 Electrolyte solution for driving electrolytic capacitor and electrolytic capacitor RUBYCON CORPORATION (JP) 2004-12-09 US claimed
WO-2004096224-A2 COMBINATIONS FOR THE TREATMENT OF DISEASES INVOLVING CELL PROLIFERATION, MIGRATION OR APOPTOSIS OF MYELOMA CELLS, OR ANGIOGENESIS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2004-11-11 WO claimed
CN-1529892-A Electrolyte for driving electrolytic capacitor and electrolytic capacitor 如碧空株式会社 2004-09-15 CN claimed
EP-1437749-A1 ELECTROLYTE SOLUTION FOR DRIVING ELECTROLYTIC CAPACITOR AND ELECTROLYTIC CAPACITOR Rubycon Corporation (JP) 2004-07-14 EP claimed
EP-1261325-A2 NITROACRIDINE/TUMOR INHIBITOR COMPOSITIONS NEW YORK MEDICAL COLLEGE (US) 2002-12-04 EP claimed
EP-1257538-A2 9-ALKYLAMINO-1-NITROACRIDINE DERIVATIVES NEW YORK MEDICAL COLLEGE (US) 2002-11-20 EP claimed
US-20020037831-A1 1-Nitroacridine/tumor inhibitor compositions TIWARI RAJ (US) 2002-03-28 US claimed
WO-2001060801-A2 9-ALKYLAMINO-1-NITROACRIDINE DERIVATIVES NEW YORK MEDICAL COLLEGE (US) 2001-08-23 WO claimed
WO-2001060351-A2 NITROACRIDINE/TUMOR INHIBITOR COMPOSITIONS NEW YORK MEDICAL COLLEGE (US) 2001-08-23 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020037831-A1 1-Nitroacridine/tumor inhibitor compositions MKI67, DIAPH1, API5 KMT2A 2779/4885MEN1 369/4885RAB9A 3078/4885
US-20050043233-A1 Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis BAX, BCL2, CXCL12 KMT2A 4366/4885MEN1 759/4885RAB9A 1623/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.