Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372579 | 0.74 | FNTA (0.49) | FNTAFNTBMDM2 | |
| SCHEMBL4374148 | 0.73 | FNTA (0.63) | FNTAFNTB | |
| SCHEMBL4371172 | 0.73 | TP53 (0.55) | FNTAFNTBRECQLMDM2LMNA | |
| SCHEMBL4372062 | 0.70 | OPRK1 (0.42) | FNTAFNTBRECQLKCNJ1LMNA | |
| SCHEMBL13501490 | 0.70 | ALDH1A1 (0.35) | FNTAFNTBRIPK1ALDH1A1KMT2A | |
| SCHEMBL1538326 | 0.65 | MDM2 (0.40) | FNTAFNTBMDM2LMNAHTT | |
| SCHEMBL6585222 | 0.65 | CYP1A2 (0.42) | LMNAALDH1A1NPC1KMT2A | |
| SCHEMBL5557771 | 0.64 | MDM2 (0.38) | FNTAFNTBMDM2ALDH1A1KMT2A | |
| SCHEMBL4376572 | 0.64 | MDM2 (0.39) | FNTAFNTBMDM2HTTL3MBTL1 | |
| SCHEMBL11448227 | 0.64 | EPAS1 (0.44) | L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339709-B1 | FARNESYL TRANSFERASE INHIBITING BENZOHETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-24 | — | — | EP | disclosed |
| US-7153958-B2 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-26 | — | — | US | disclosed |