Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 3/20 | 0.74 |
| ▸ | MLNR | O43193 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CTSD | P07339 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.53 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.53 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1051190 | 1.00 | SPPL2A (0.74) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL9605440 | 1.00 | SPPL2A (0.74) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL10031792 | 1.00 | SPPL2A (0.74) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL23129692 | 1.00 | SPPL2A (0.74) | SPPL2AMLNRABCB11LMNACTSD | |
| Hydrochloric Acid SCHEMBL14637729 | 0.99 | SPPL2A (0.73) | SPPL2AMLNRABCB11LMNACTSD | |
| Hydrochloric Acid SCHEMBL14636197 | 0.99 | SPPL2A (0.73) | SPPL2AMLNRABCB11LMNACTSD | |
| Sulfuric Acid SCHEMBL18281506 | 0.98 | SPPL2A (0.72) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL4373559 | 0.94 | SPPL2A (0.76) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL4911140 | 0.94 | SPPL2A (0.76) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL1054059 | 0.92 | SPPL2A (0.73) | SPPL2AMLNRABCB11LMNACTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11427599-B2 | Simplified procedure for the preparation of darunavir | Janssen Sciences Ireland Unlimited Company (IE) | 2022-08-30 | — | — | US | claimed |
| US-20210139495-A1 | SIMPLIFIED PROCEDURE FOR THE PREPARATION OF DARUNAVIR | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-05-13 | — | — | US | claimed |
| EP-3541819-B1 | A SIMPLIFIED PROCEDURE FOR THE PREPARATION OF DARUNAVIR | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2020-12-09 | — | — | EP | claimed |
| EP-2877474-B1 | A PROCESS FOR PREPARATION OF DARUNAVIR | LAURUS LABS LTD (IN) | 2020-11-04 | — | — | EP | claimed |
| US-10774088-B2 | Simplified procedure for the preparation of darunavir | Janssen Sciences Ireland Unlimited Company (IE) | 2020-09-15 | — | — | US | claimed |
| EP-3541819-A1 | A SIMPLIFIED PROCEDURE FOR THE PREPARATION OF DARUNAVIR | Janssen Sciences Ireland Unlimited Company (IE) | 2019-09-25 | — | — | EP | claimed |
| WO-2018091559-A1 | A SIMPLIFIED PROCEDURE FOR THE PREPARATION OF DARUNAVIR | JANSSEN SCIENCES IRELAND UC (IE) | 2018-05-24 | — | — | WO | claimed |
| US-9475821-B2 | Process for preparation of Darunavir | LAURUS LABS PRIVATE LIMITED (IN) | 2016-10-25 | — | — | US | claimed |
| US-20150203506-A1 | PROCESS FOR PREPARATION OF DARUNAVIR | LAURUS LABS PRIVATE LTD. (IN) | 2015-07-23 | — | — | US | claimed |
| US-20150141383-A1 | Darunavir Polymorph and Process for Preparation Thereof | CIPLA LIMITED (IN) | 2015-05-21 | — | — | US | claimed |
| US-20130029945-A1 | Darunavir Polymorph and Process for Preparation Thereof | CIPLA LIMITED (IN) | 2013-01-31 | — | — | US | claimed |
| EP-2521728-A2 | DARUNAVIR POLYMORPH AND PROCESS FOR PREPARATION THEREOF | Cipla Limited (IN) | 2012-11-14 | — | — | EP | claimed |
| WO-2011083287-A2 | DARUNAVIR POLYMORPH AND PROCESS FOR PREPARATION THEREOF | CIPLA LIMITED (IN) | 2011-07-14 | — | — | WO | claimed |
| US-20050032889-A1 | Process for producing crystal of benzenesulfonamide derivative, and novel crystal of intermediate therefor and process for producing the same | AJINOMOTO CO., INC (JP) | 2005-02-10 | — | — | US | claimed |
| EP-1466896-A1 | PROCESS FOR PRODUCING CRYSTAL OF BENZENESULFONAMIDE DERIVATIVE, AND NOVEL CRYSTAL OF INTERMEDIATE THEREFOR AND PROCESS FOR PRODUCING THE SAME | Ajinomoto Co., Inc. (JP) | 2004-10-13 | — | — | EP | claimed |
| US-11427599-B2 | Simplified procedure for the preparation of darunavir | Janssen Sciences Ireland Unlimited Company (IE) | 2022-08-30 | — | — | US | disclosed |
| US-11427599-B2 | Simplified procedure for the preparation of darunavir | Janssen Sciences Ireland Unlimited Company (IE) | 2022-08-30 | — | — | US | disclosed |
| US-20050131042-A1 | HIV protease inhibiting compounds | ABBOTT LABORATORIES | 2005-06-16 | — | — | US | disclosed |
| US-20050032889-A1 | Process for producing crystal of benzenesulfonamide derivative, and novel crystal of intermediate therefor and process for producing the same | AJINOMOTO CO., INC (JP) | 2005-02-10 | — | — | US | disclosed |
| EP-1466896-A1 | PROCESS FOR PRODUCING CRYSTAL OF BENZENESULFONAMIDE DERIVATIVE, AND NOVEL CRYSTAL OF INTERMEDIATE THEREFOR AND PROCESS FOR PRODUCING THE SAME | Ajinomoto Co., Inc. (JP) | 2004-10-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774088-B2 | Simplified procedure for the preparation of darunavir | ADH1A, CYP3A43, DERA | SPPL2A 1582/4885MLNR 2422/4885ABCB11 2200/4885 |
| US-20130029945-A1 | Darunavir Polymorph and Process for Preparation Thereof | SAMHD1, CYP3A4, CYP3A43 | SPPL2A 3725/4885MLNR 3663/4885ABCB11 553/4885 |
| US-20150203506-A1 | PROCESS FOR PREPARATION OF DARUNAVIR | SAMHD1, DARS1, CYP3A43 | SPPL2A 4534/4885MLNR 3568/4885ABCB11 788/4885 |
| US-20150141383-A1 | Darunavir Polymorph and Process for Preparation Thereof | SAMHD1, CYP3A4, CYP3A43 | SPPL2A 3725/4885MLNR 3663/4885ABCB11 553/4885 |
| US-20050032889-A1 | Process for producing crystal of benzenesulfonamide derivative, and novel crystal of intermediate therefor and process for producing the same | WEE1, WEE2, NOTUM | SPPL2A 3302/4885MLNR 3897/4885ABCB11 861/4885 |
| US-20210139495-A1 | SIMPLIFIED PROCEDURE FOR THE PREPARATION OF DARUNAVIR | ADH1A, CYP3A43, DERA | SPPL2A 1610/4885MLNR 2358/4885ABCB11 2068/4885 |
| US-11427599-B2 | Simplified procedure for the preparation of darunavir | ADH1A, CYP3A43, DERA | SPPL2A 1610/4885MLNR 2358/4885ABCB11 2068/4885 |
| US-20050131042-A1 | HIV protease inhibiting compounds | SERPINB1, HPN, DNPEP | SPPL2A 1106/4885MLNR 3723/4885ABCB11 2264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.