Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9468178 | 0.76 | KDM4E (0.33) | GAAALDH1A1KDM4E | |
| SCHEMBL4372931 | 0.73 | MAPKAPK2 (0.45) | POLBCXCR2MAPK1SMN1; SMN2HTT | |
| SCHEMBL19956899 | 0.71 | MEN1 (0.63) | MEN1KMT2ACTDSP1POLBTAAR1 | |
| SCHEMBL9467372 | 0.69 | LMNA (0.40) | MEN1KMT2APOLBHPGDPKM | |
| SCHEMBL20927269 | 0.68 | MEN1 (0.63) | MEN1KMT2ACTDSP1POLBTAAR1 | |
| SCHEMBL16144154 | 0.68 | KMT2A (0.50) | MEN1KMT2ACTDSP1POLBTAAR1 | |
| SCHEMBL16264714 | 0.67 | MEN1 (0.56) | MEN1KMT2ACTDSP1POLBTAAR1 | |
| SCHEMBL11790466 | 0.64 | SIGMAR1 (0.64) | SIGMAR1HPGDL3MBTL1HDAC3ALDH1A1 | |
| SCHEMBL11799937 | 0.64 | SIGMAR1 (0.64) | SIGMAR1HPGDL3MBTL1HDAC3ALDH1A1 | |
| SCHEMBL11802956 | 0.64 | SIGMAR1 (0.64) | SIGMAR1HPGDL3MBTL1HDAC3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |