SCHEMBL4375355

SCHEMBL4375355

C=Cc1ccc(C(C)C[SiH2]OC)cc1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.38
TAS1R3 Q7RTX0 1/20 0.35
TAS1R1 Q7RTX1 1/20 0.35
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA7 P36544 1/20 0.32
CHRNA4 P43681 1/20 0.32
TRPA1 O75762 1/20 0.32
HDAC8 Q9BY41 1/20 0.31
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL699213 0.77 ALDH1A1 (0.42) ALDH1A1TAS1R3TAS1R1CHRNB2CHRNB4
SCHEMBL11517329 0.74 ALDH1A1 (0.48) ALDH1A1TAS1R3TAS1R1CHRNB2CHRNB4
SCHEMBL716407 0.74 ALDH1A1 (0.48) ALDH1A1TAS1R3TAS1R1CHRNB2CHRNB4
SCHEMBL1270717 0.72 ALDH1A1 (0.38) ALDH1A1TAS1R3TAS1R1CHRNB2CHRNB4
SCHEMBL3671591 0.72 ALDH1A1 (0.46) ALDH1A1TAS1R3TAS1R1CHRNB2CHRNB4
SCHEMBL2467595 0.72 ALDH1A1 (0.46) ALDH1A1TAS1R3TAS1R1CHRNB2CHRNB4
SCHEMBL220825 0.72 ALDH1A1 (0.46) ALDH1A1TAS1R3TAS1R1CHRNB2CHRNB4
SCHEMBL28338609 0.71 ALDH1A1 (0.41) ALDH1A1TAS1R3TAS1R1CHRNB2CHRNB4
SCHEMBL6281654 0.71 ESR1 (0.57) ALDH1A1TAS1R3TAS1R1HDAC8TSHR
SCHEMBL5024850 0.71 TAS1R3 (0.46) ALDH1A1TAS1R3TAS1R1CHRNB2CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1383470-B1 HAIR TREATMENT COMPOSITIONS UNILEVER PLC (GB) 2009-06-17 EP disclosed
EP-1383469-B1 HAIR TREATMENT COMPOSITIONS UNILEVER PLC (GB) 2006-02-15 EP disclosed
EP-1383860-B1 FABRIC CARE COMPOSITIONS UNILEVER PLC (GB) 2005-10-12 EP disclosed
US-6767883-B2 Fabric care compositions UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC. 2004-07-27 US disclosed
US-6696050-B2 COATED PARTICLES COMPRISING (A) A SOLID CORE HAVING A D3, 2 AVERAGE PARTICLE SIZE IN THE RANGE FROM 10 TO 700 NM, AND (B) A COATING POLYMER COVALENTLY BONDED TO THE SOLID CORE; E.G., SOLID SILICA CORES AND POLYSTYRENE COATING POLYMER UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-02-24 US disclosed
US-6696051-B2 CONTAINING CORE PARTICLES HAVING A D3,2 AVERAGE PARTICLE SIZE OF 10-700 NM, AND COATED WITH COVALENTLY BONDED SILICONE POLYMER UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-02-24 US disclosed
EP-1383468-A2 HAIR TREATMENT COMPOSITIONS UNILEVER PLC (GB) 2004-01-28 EP disclosed
US-20030095943-A1 Hair treatment compositions UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2003-05-22 US disclosed
US-20030012757-A1 Hair treatment compositions UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2003-01-16 US disclosed
US-20020192367-A1 Fabric care compositions UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2002-12-19 US disclosed
WO-2002087522-A2 HAIR TREATMENT COMPOSITIONS UNILEVER PLC (GB) 2002-11-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030095943-A1 Hair treatment compositions SPTLC3, HACD3, C18orf63 ALDH1A1 379/4885TAS1R3 354/4885TAS1R1 1402/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.