Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATP4A | P20648 | 1/20 | 0.36 |
| ▸ | ATP4B | P51164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6381401 | 0.82 | HPGDS (0.54) | KDM4ESLC6A3SRCHPGDSEGFR | |
| SCHEMBL24009065 | 0.80 | ALDH1A1 (0.43) | KDM4ECYP3A4SLC6A3SRCL3MBTL1 | |
| SCHEMBL24009072 | 0.77 | SLC6A3 (0.40) | KDM4ESLC6A3SRCHPGDSPIN1 | |
| SCHEMBL5256736 | 0.76 | IMPDH2 (0.48) | KDM4ESLC6A3SRCHPGDSEGFR | |
| SCHEMBL10500041 | 0.76 | MAPK1 (0.42) | KDM4ETDP1GAAMAOB | |
| SCHEMBL27848687 | 0.74 | KDM4E (0.58) | KDM4ECYP3A4ALOX12TDP1HSP90AA1 | |
| SCHEMBL13671174 | 0.73 | SRC (0.43) | SRCEGFRERBB2 | |
| SCHEMBL13427142 | 0.72 | SRC (0.55) | SRCEGFRERBB2 | |
| SCHEMBL29241289 | 0.72 | KDM4E (0.78) | KDM4ECYP3A4ALOX12TDP1HSP90AA1 | |
| SCHEMBL19889981 | 0.72 | SLC6A3 (0.41) | KDM4ESLC6A3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696914-B1 | 3-CYANO-QUINOLINE DERIVATIVES WITH ANTIPROLIFERATIVE ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-28 | — | — | EP | claimed |