Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNB4 | O00305 | 2/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.45 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.45 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.45 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.45 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.45 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.45 |
| ▸ | CACNA1E | Q15878 | 2/20 | 0.45 |
| ▸ | CACNA2D4 | Q7Z3S7 | 2/20 | 0.45 |
| ▸ | CACNA2D3 | Q8IZS8 | 2/20 | 0.45 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27889061 | 0.83 | DBH (0.41) | POLBHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4384076 | 0.81 | KCNA3 (0.46) | MAPTTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29136198 | 0.79 | MAPT (0.46) | MAPTTP53KCNH2MEN1KMT2A | |
| SCHEMBL29136189 | 0.78 | MAPT (0.47) | MAPTTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27905750 | 0.78 | HTT (0.49) | MAPTMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL27751725 | 0.77 | HDAC8 (0.40) | MAPTTP53POLBHTTSMN1; SMN2 | |
| SCHEMBL27751735 | 0.77 | ICMT (0.41) | KCNH2MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL3079071 | 0.76 | LMNA (0.50) | MAPTTP53POLBMEN1KMT2A | |
| SCHEMBL27889088 | 0.73 | MEN1 (0.47) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL4383614 | 0.73 | MEN1 (0.47) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102850324-A | Indole compounds | MICROBIA INC | 2013-01-02 | — | — | CN | disclosed |
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |