Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440196 | 0.92 | NPC1 (0.52) | NPC1RAB9AKMT2AAURKBMEN1 | |
| SCHEMBL440489 | 0.89 | DPP4 (0.53) | NPC1RAB9AKMT2AAURKBMEN1 | |
| SCHEMBL438246 | 0.89 | DPP4 (0.56) | NPC1RAB9AKMT2AAURKBMEN1 | |
| SCHEMBL440425 | 0.82 | KMT2A (0.68) | NPC1RAB9AKMT2AAURKBMEN1 | |
| SCHEMBL436903 | 0.82 | KMT2A (0.65) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL437101 | 0.82 | KMT2A (0.65) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL437138 | 0.81 | NPC1 (0.56) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL440159 | 0.78 | MAPT (0.62) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL440068 | 0.78 | HAVCR2 (0.63) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL440854 | 0.76 | AURKA (0.57) | NPC1RAB9AKMT2AAURKBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |