Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049767 | 0.86 | AURKA (0.55) | AURKAAURKBKMT2AALDH1A1MAPT | |
| SCHEMBL436657 | 0.80 | KDM4E (0.59) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL440378 | 0.79 | HAVCR2 (0.49) | AURKAAURKBKMT2AALDH1A1MAPT | |
| SCHEMBL439424 | 0.79 | NPC1 (0.45) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL25999187 | 0.77 | ALDH1A1 (0.47) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL438266 | 0.77 | KMT2A (0.47) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL441687 | 0.77 | KMT2A (0.62) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL437796 | 0.76 | NPC1 (0.54) | AURKBNPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL9727774 | 0.76 | ALDH1A1 (0.71) | KMT2AALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL25999202 | 0.76 | DPP4 (0.51) | NPC1RAB9AKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |