Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3002008 | 0.97 | LMNA (0.47) | LMNAALDH1A1MAPTALOX12SIGMAR1 | |
| SCHEMBL3009940 | 0.96 | LMNA (0.46) | LMNAALDH1A1MAPTALOX12SIGMAR1 | |
| SCHEMBL3008504 | 0.95 | LMNA (0.47) | LMNAALDH1A1MAPTALOX12SIGMAR1 | |
| SCHEMBL2995773 | 0.95 | ALDH1A1 (0.46) | LMNAALDH1A1MAPTALOX12SIGMAR1 | |
| SCHEMBL2998712 | 0.94 | ALDH1A1 (0.47) | LMNAALDH1A1MAPTALOX12SIGMAR1 | |
| SCHEMBL3001380 | 0.93 | LMNA (0.48) | LMNAALDH1A1MAPTALOX12SIGMAR1 | |
| SCHEMBL3005711 | 0.93 | LMNA (0.43) | LMNAALDH1A1MAPTALOX12SIGMAR1 | |
| SCHEMBL2991069 | 0.91 | SIGMAR1 (0.43) | LMNAALDH1A1MAPTALOX12SIGMAR1 | |
| SCHEMBL3002533 | 0.90 | MAPT (0.43) | LMNAALDH1A1MAPTALOX12SIGMAR1 | |
| SCHEMBL3004493 | 0.89 | ALDH1A1 (0.44) | LMNAALDH1A1MAPTALOX12SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |