Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362296 | 0.79 | CYP3A4 (0.48) | L3MBTL1CYP3A4CYP2C9MAPKAPK2ROCK1 | |
| SCHEMBL9668473 | 0.76 | GAA (0.57) | HTTPOLBALDH1A1MEN1LMNA | |
| Trifluoroacetic Acid SCHEMBL4560397 | 0.72 | CXCR2 (0.44) | LMNACYP3A4CYP2C9MAPKAPK2ROCK1 | |
| SCHEMBL9380274 | 0.69 | KMT2A (0.87) | HTTPOLBALDH1A1MEN1LMNA | |
| SCHEMBL17920542 | 0.68 | MAPKAPK2 (0.80) | CYP3A4CYP2C9MAPKAPK2ROCK1AURKB | |
| SCHEMBL4371405 | 0.68 | ALDH1A1 (0.58) | HTTALDH1A1MEN1LMNAMAPT | |
| SCHEMBL15613273 | 0.67 | HTT (1.00) | HTTPOLBMEN1MAPTKMT2A | |
| SCHEMBL4374908 | 0.67 | MAPKAPK2 (0.55) | MEN1KMT2ACYP3A4CYP2C9MAPKAPK2 | |
| SCHEMBL3225224 | 0.66 | MEN1 (0.51) | POLBALDH1A1MEN1LMNAMAPT | |
| SCHEMBL27991724 | 0.66 | POLB (0.50) | HTTPOLBALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | claimed |
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |