Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4396461 | 0.88 | SLC26A3 (0.43) | SMN1; SMN2NPC1RAB9AHDAC6SMPD1 | |
| SCHEMBL4386765 | 0.87 | SMPD1 (0.44) | ALDH1A1SMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL4384794 | 0.86 | PLA2G2A (0.41) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29291239 | 0.72 | GAA (0.54) | ALDH1A1MAPTMEN1LMNAGAA | |
| SCHEMBL4380214 | 0.72 | SGMS2 (0.43) | ALDH1A1MAPTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL4383171 | 0.72 | PTGER1 (0.48) | SMN1; SMN2NPC1RAB9ABRD4MAPK14 | |
| SCHEMBL4380278 | 0.71 | HPGD (0.42) | ALDH1A1SMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL4389290 | 0.71 | MAPK14 (0.39) | ALDH1A1MAPTRAB9AMAPK14 | |
| SCHEMBL31528182 | 0.70 | SMPD1 (0.50) | ALDH1A1SMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL31528255 | 0.70 | BRD4 (0.49) | ALDH1A1MAPTSMN1; SMN2HDAC6SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538241-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20070155813-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
| EP-1704856-A1 | HSP90 FAMILY PROTEIN INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-09-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155813-A1 | Hsp90 family protein inhibitors | HSP90AB1, HEATR1, HSP90AB2P | ALDH1A1 3520/4885MAPT 2443/4885SMN1; SMN2 4471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.