Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | BRS3 | P32247 | 4/20 | 0.44 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HNF4A | P41235 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.42 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 3/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.42 |
| ▸ | KDM6B | O15054 | 2/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.42 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428237 | 0.91 | KDM4E (0.50) | KDM4EBRS3HNF4APTPN1LMNA | |
| SCHEMBL3912930 | 0.91 | KDM4E (0.53) | KDM4EBRS3HNF4APTPN1KDM4A | |
| SCHEMBL4430692 | 0.87 | KDM4E (0.51) | KDM4EACMSDHNF4APTPN1DCLRE1A | |
| SCHEMBL4426842 | 0.85 | KDM4E (0.49) | KDM4EGAALMNATSHRALDH1A1 | |
| SCHEMBL11836193 | 0.84 | KDM4E (0.42) | KDM4EHNF4AGAATSHRKDM4A | |
| SCHEMBL4432424 | 0.84 | HNF4A (0.49) | KDM4EACMSDHNF4APTPN1KDM4A | |
| SCHEMBL4430485 | 0.83 | KDM4E (0.41) | KDM4EGAAKDM4AKDM5BKDM6B | |
| SCHEMBL3917621 | 0.83 | DAO (0.46) | KDM4EBRS3KDM4AKDM5BKDM6B | |
| SCHEMBL3920671 | 0.83 | DAO (0.54) | KDM4EBRS3GAALMNATSHR | |
| SCHEMBL4431596 | 0.82 | KDM4E (0.45) | KDM4EHNF4ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |