SCHEMBL4379746

SCHEMBL4379746

COc1cc2c(=O)nc[nH]c2cc1OCCCN1CCSCC1

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
EHMT2 Q96KQ7 6/20 0.43
EHMT1 Q9H9B1 6/20 0.43
SPIN1 Q9Y657 3/20 0.43
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40
MAPT P10636 1/20 0.40
KDR P35968 1/20 0.40
RCE1 Q9Y256 1/20 0.40
MET P08581 1/20 0.40
TLR9 Q9NR96 1/20 0.39
TLR7 Q9NYK1 1/20 0.39
EGFR P00533 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4373778 0.89 EHMT2 (0.52) EHMT2EHMT1SPIN1KDM4EALDH1A1
SCHEMBL28431957 0.87 KDM4E (0.53) KDM4EALDH1A1KDRRCE1EGFR
SCHEMBL1734718 0.87 KDM4E (0.53) KDM4EALDH1A1KDRRCE1EGFR
Hydrochloric Acid SCHEMBL4378498 0.86 KDM4E (0.52) KDM4EALDH1A1KDRRCE1EGFR
SCHEMBL4379749 0.83 EHMT2 (0.50) EHMT2EHMT1SPIN1KDRMET
SCHEMBL3329620 0.79 PDE3B (0.40) KDM4EALDH1A1HPGDHSD17B10MAPT
SCHEMBL4376396 0.79 PDE3B (0.40) KDM4EALDH1A1HPGDHSD17B10MAPT
SCHEMBL4375766 0.78 PDE3B (0.39) KDM4EALDH1A1HPGDHSD17B10MAPT
SCHEMBL4297391 0.78 PRKAB2 (0.42) EHMT2KDM4EALDH1A1HPGDKDR
SCHEMBL6488287 0.77 SRC (0.43) EHMT2EHMT1SPIN1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050080262-A1 Process for producing quinazolin-4-one derivative UBE INDUSTRIES, LTD. (JP) 2005-04-14 US claimed
EP-1477481-A1 PROCESS FOR PRODUCING QUINAZOLIN-4-ONE DERIVATIVE Ube Industries, Ltd. (JP) 2004-11-17 EP claimed
US-8367824-B2 Reacting anthranilic acid with formic acid compound in presence of a catalyst and solvent UBE INDUSTRIES LTD. (JP) 2013-02-05 US disclosed
EP-1477481-B1 PROCESS FOR PRODUCING QUINAZOLIN-4-ONE DERIVATIVE UBE INDUSTRIES (JP) 2009-07-22 EP disclosed
US-20050080262-A1 Process for producing quinazolin-4-one derivative UBE INDUSTRIES, LTD. (JP) 2005-04-14 US disclosed
EP-1477481-A1 PROCESS FOR PRODUCING QUINAZOLIN-4-ONE DERIVATIVE Ube Industries, Ltd. (JP) 2004-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050080262-A1 Process for producing quinazolin-4-one derivative NQO2, SDHA, CYP3A4 EHMT2 2872/4885EHMT1 2444/4885SPIN1 3548/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.