Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.37 |
| ▸ | HPGDS | O60760 | 5/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379225 | 0.85 | ANPEP (0.36) | HDAC1HDAC3HDAC4HPGDSBACE1 | |
| SCHEMBL4384197 | 0.78 | HDAC1 (0.47) | HDAC1HDAC3HDAC4HDAC6HPGDS | |
| SCHEMBL1529619 | 0.76 | HDAC3 (0.37) | HDAC1HDAC3HDAC4HDAC6HPGDS | |
| SCHEMBL12679232 | 0.75 | SYK (0.38) | HDAC1HDAC3HDAC4HDAC6USP30 | |
| SCHEMBL8233879 | 0.74 | PIN1 (0.41) | BACE1TP53HPGD | |
| SCHEMBL4541679 | 0.72 | AKT1 (0.41) | HDAC1HDAC3HDAC4HDAC6HPGDS | |
| SCHEMBL4582625 | 0.72 | ALDH1A1 (0.44) | HDAC1HDAC3HDAC4HDAC6LMNA | |
| SCHEMBL1164824 | 0.71 | USP30 (0.36) | USP30F2PRSS1 | |
| SCHEMBL2786387 | 0.71 | KDM4E (0.43) | LMNAALDH1A1HPGDUSP30SMN1; SMN2 | |
| SCHEMBL1529917 | 0.70 | PIN1 (0.37) | HDAC4HDAC6HPGDSLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |