Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | LAP3 | P28838 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.33 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.33 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.33 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.33 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.33 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.33 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.33 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.33 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.33 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.33 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379925 | 0.85 | HDAC1 (0.38) | BACE1HPGDHPGDSSMN1; SMN2HDAC3 | |
| SCHEMBL8233879 | 0.80 | PIN1 (0.41) | ANPEPLAP3BACE1HPGDCTSL | |
| SCHEMBL4382189 | 0.79 | ACKR3 (0.43) | HPGDCTSLL3MBTL1KMT2ANPC1 | |
| SCHEMBL4375386 | 0.79 | ACKR3 (0.43) | HPGDCTSLL3MBTL1KMT2ANPC1 | |
| SCHEMBL1529917 | 0.77 | PIN1 (0.37) | ANPEPLAP3HPGDPSMB11PSMA7 | |
| SCHEMBL4583485 | 0.74 | ALDH1A1 (0.47) | HPGDHPGDSCTSLL3MBTL1KMT2A | |
| SCHEMBL4374524 | 0.74 | ALDH1A1 (0.47) | HPGDHPGDSCTSLL3MBTL1KMT2A | |
| SCHEMBL4378512 | 0.74 | AKT1 (0.40) | HPGDL3MBTL1KMT2APIN1 | |
| SCHEMBL4544034 | 0.73 | HPGDS (0.38) | HPGDSDYRK1ADYRK1BHDAC3HDAC4 | |
| SCHEMBL4543913 | 0.72 | HPGDS (0.36) | HPGDSDYRK1ADYRK1BHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |