Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384554 | 0.91 | GSK3B (0.37) | ALDH1A1KDM4EBRD4BRPF1GPR6 | |
| SCHEMBL4378591 | 0.88 | GSK3B (0.38) | BRD4BRPF1MAPTGAAGSK3B | |
| SCHEMBL4387999 | 0.80 | GSK3B (0.37) | ALDH1A1TSHRGSK3BSMN1; SMN2 | |
| SCHEMBL4387224 | 0.80 | ALDH1A1 (0.36) | ALDH1A1KDM4EGPR6MAPTGAA | |
| SCHEMBL4952879 | 0.78 | MEN1 (0.47) | ALDH1A1KDM4EGPR6KMT2AMEN1 | |
| SCHEMBL4383616 | 0.77 | MEN1 (0.47) | ALDH1A1BRD4BRPF1GPR6GAA | |
| SCHEMBL2066100 | 0.77 | GSK3B (0.43) | ALDH1A1MAPTGSK3BKMT2AGLA | |
| SCHEMBL4377844 | 0.75 | MEN1 (0.45) | BRD4BRPF1GPR6MAPTGAA | |
| SCHEMBL4385699 | 0.73 | GSK3B (0.35) | GSK3B | |
| SCHEMBL3373754 | 0.72 | OPRD1 (0.41) | GAAGSK3BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | claimed |