Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384690 | 0.85 | KCNH2 (0.34) | KCNH2CYP2D6 | |
| SCHEMBL4376189 | 0.84 | KCNH2 (0.37) | HRH3KCNH2LMNASMN1; SMN2CYP2D6 | |
| SCHEMBL4381458 | 0.82 | GAA (0.40) | HRH3KCNH2 | |
| SCHEMBL4386689 | 0.79 | LMNA (0.45) | HRH3KCNH2LMNASMN1; SMN2CYP2D6 | |
| SCHEMBL7987297 | 0.79 | HRH3 (0.54) | HRH3KCNH2LMNASMN1; SMN2 | |
| SCHEMBL4379716 | 0.78 | MEN1 (0.37) | — | |
| SCHEMBL7991257 | 0.77 | CYP3A4 (0.45) | LMNASMN1; SMN2CYP2D6 | |
| SCHEMBL4376133 | 0.76 | HRH3 (0.46) | HRH3KCNH2CYP2D6 | |
| SCHEMBL4390109 | 0.76 | KCNH2 (0.39) | HRH3KCNH2CYP2D6 | |
| SCHEMBL4380966 | 0.76 | NQO1 (0.45) | HRH3KCNH2LMNASMN1; SMN2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996030048-A1 | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-10-03 | — | — | WO | disclosed |