Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376133 | 0.85 | HRH3 (0.46) | KCNH2CYP3A4CYP2D6CYP2C9HRH3 | |
| SCHEMBL4386689 | 0.85 | LMNA (0.45) | KCNH2CYP3A4CYP2D6CYP2C9HRH3 | |
| SCHEMBL4376189 | 0.82 | KCNH2 (0.37) | KCNH2CYP3A4CYP2D6CYP2C9HRH3 | |
| SCHEMBL7991257 | 0.82 | CYP3A4 (0.45) | CYP3A4CYP2D6CYP2C9ALDH1A1KMT2A | |
| SCHEMBL7961327 | 0.81 | RAB9A (0.43) | KCNH2HRH3ALDH1A1KMT2A | |
| SCHEMBL7987297 | 0.81 | HRH3 (0.54) | KCNH2CYP3A4CYP2C9HRH3ALDH1A1 | |
| SCHEMBL4380966 | 0.81 | NQO1 (0.45) | KCNH2CYP3A4CYP2D6CYP2C9HRH3 | |
| SCHEMBL4381050 | 0.81 | KCNH2 (0.36) | KCNH2CYP3A4CYP2D6CYP2C9HRH3 | |
| SCHEMBL7988201 | 0.80 | FFAR1 (0.37) | KCNH2CYP3A4CYP2D6CYP2C9HRH3 | |
| SCHEMBL4386635 | 0.79 | RAB9A (0.48) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |