Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973104 | 0.92 | MAPT (0.43) | LMNASMN1; SMN2ALDH1A1MAPTHPGD | |
| Oxalic Acid SCHEMBL7990912 | 0.92 | MEN1 (0.47) | LMNASMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL7991257 | 0.88 | CYP3A4 (0.45) | LMNASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL4380966 | 0.88 | NQO1 (0.45) | LMNASMN1; SMN2ALDH1A1MAPTHRH3 | |
| SCHEMBL4390109 | 0.85 | KCNH2 (0.39) | ALDH1A1MAPTHRH3KCNH2CYP3A4 | |
| SCHEMBL4376133 | 0.85 | HRH3 (0.46) | HRH3KCNH2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7987297 | 0.84 | HRH3 (0.54) | LMNASMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL4392060 | 0.83 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1NPC1KDM4ETSHR | |
| SCHEMBL4378580 | 0.83 | KDM4E (0.43) | LMNASMN1; SMN2ALDH1A1HRH3KDM4E | |
| SCHEMBL4376189 | 0.82 | KCNH2 (0.37) | LMNASMN1; SMN2ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | claimed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | claimed |
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |