Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988201 | 0.89 | FFAR1 (0.37) | KCNH2ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL4382446 | 0.84 | HRH3 (0.35) | KCNH2LMNASMN1; SMN2CYP2D6HRH3 | |
| SCHEMBL4384169 | 0.84 | ALDH1A1 (0.48) | KCNH2ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL4384690 | 0.84 | KCNH2 (0.34) | KCNH2FFAR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4386689 | 0.82 | LMNA (0.45) | KCNH2ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL4376133 | 0.82 | HRH3 (0.46) | KCNH2FFAR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4390109 | 0.82 | KCNH2 (0.39) | KCNH2ALDH1A1MAPTCYP3A4CYP2D6 | |
| SCHEMBL4384666 | 0.81 | LTA4H (0.33) | KCNH2MAPTFFAR1HRH3 | |
| SCHEMBL4386379 | 0.81 | KCNH2 (0.35) | KCNH2MAPTSMN1; SMN2HRH3 | |
| SCHEMBL7991257 | 0.80 | CYP3A4 (0.45) | ALDH1A1LMNASMN1; SMN2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | claimed |
| WO-1996029298-A1 | PROCESS FOR PRODUCING POLYFLUOROACYL COMPOSITIONS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-09-26 | — | — | WO | claimed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |
| US-4910348-A | Reacting a polyfluoroalcoholate with a strong base | CENTRAL GLASS COMPANY, LIMITED (JP) | 1990-03-20 | — | — | US | disclosed |