Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 13/20 | 0.83 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.57 |
| ▸ | OGA | O60502 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005317 | 0.91 | HTR7 (1.00) | HTR7ADRA1DADRA1AADRA1BOGA | |
| SCHEMBL7006872 | 0.83 | HTR7 (0.81) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4376845 | 0.81 | HTR7 (0.76) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4380313 | 0.81 | HTR7 (0.76) | HTR7ADRA1DADRA1AADRA1BOGA | |
| SCHEMBL4540550 | 0.79 | HTR7 (0.73) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4379572 | 0.77 | HTR7 (0.74) | HTR7ADRA1DADRA1AADRA1BOGA | |
| SCHEMBL7009556 | 0.77 | HTR7 (0.74) | HTR7ADRA1DADRA1AADRA1BOGA | |
| SCHEMBL7006812 | 0.77 | HTR7 (1.00) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7011314 | 0.77 | HTR7 (1.00) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4377313 | 0.76 | HTR7 (0.47) | HTR7OGAMKNK1MKNK2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-B1 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-18 | — | — | EP | disclosed |