Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 16/20 | 0.76 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005317 | 0.87 | HTR7 (1.00) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7006872 | 0.86 | HTR7 (0.81) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4375545 | 0.86 | HTR7 (0.54) | HTR7ALDH1A1LMNATP53TSHR | |
| SCHEMBL4382987 | 0.81 | HTR7 (0.83) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4375490 | 0.80 | HTR7 (0.69) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7006812 | 0.80 | HTR7 (1.00) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7011314 | 0.80 | HTR7 (1.00) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4380313 | 0.77 | HTR7 (0.76) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7014074 | 0.77 | HTR7 (0.54) | HTR7ADRA1DADRA1AADRA1BSLC2A1 | |
| SCHEMBL4540550 | 0.75 | HTR7 (0.73) | HTR7ADRA1DADRA1AADRA1BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-B1 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-18 | — | — | EP | claimed |