SCHEMBL4383010

SCHEMBL4383010

O=CCc1ccc(Oc2ccc(O)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.58
ESR2 Q92731 3/20 0.58
MEN1 O00255 1/20 0.58
KMT2A Q03164 1/20 0.58
LTA4H P09960 7/20 0.50
NR1H2 P55055 1/20 0.50
BAX Q07812 1/20 0.50
PARP10 Q53GL7 1/20 0.47
CALM1 P0DP23 1/20 0.41
APP P05067 1/20 0.41
PTPN1 P18031 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL105690 0.87 ESR1 (0.52) ESR1ESR2MEN1KMT2ALTA4H
SCHEMBL27814857 0.82 ALDH1A1 (0.57) ESR1ESR2MEN1KMT2ALTA4H
SCHEMBL5324129 0.81 LTA4H (0.57) LTA4HNR1H2BAXPARP10
SCHEMBL6446133 0.79 MAOB (0.48) LTA4HAPP
SCHEMBL4457868 0.79 ALDH1A1 (0.59) MEN1KMT2ALTA4HPARP10
SCHEMBL5563797 0.79 LTA4H (0.47) KMT2ALTA4HAPP
SCHEMBL6243400 0.79 APP (0.47) LTA4HAPP
SCHEMBL14782754 0.79 ALDH1A1 (0.58) MEN1KMT2APARP10
SCHEMBL14421265 0.78 ESR1 (0.70) ESR1ESR2MEN1KMT2ALTA4H
SCHEMBL12804316 0.78 ESR1 (0.70) ESR1ESR2MEN1KMT2ALTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009118747-A1 NOVEL HYDROXY FUNCTIONALIZED 1, 2, 4-TRIOXANES AS ANTIMALARIAL AGENTS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2009-10-01 WO disclosed
EP-2013176-A2 DIARYL COMPOUNDS AS NON-STEROIDAL INHIBITORS OF 17-BETA HYDROXYSTEROID DEHYDROGENASE AND/OR STEROID SULPHATASE FOR THE TREATMENT OF OESTROGEN-RELATED DISEASES SUCH AS HORMONE DEPENDENT BREAST CANCER Sterix Limited (GB) 2009-01-14 EP disclosed
EP-1926708-A1 BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION Decode Chemistry, Inc. (US) 2008-06-04 EP disclosed
WO-2007096647-A2 DIARYL COMPOUNDS AS NON-STEROIDAL INHIBITORS OF 17-BETA HYDROXYSTEROID DEHYDROGENASE AND/OR STEROID SULPHATASE FOR THE TREATMENT OF OESTROGEN-RELATED DISEASES SUCH AS HORMONE DEPENDENT BREAST CANCER STERIX LIMITED (GB) 2007-08-30 WO disclosed
WO-2007040681-A1 BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION DECODE GENETICS EHF (IS) 2007-04-12 WO disclosed
WO-2007040682-A1 BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION DECODE GENETICS EHF. (IS) 2007-04-12 WO disclosed