Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 8/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.33 |
| ▸ | EDNRB | P24530 | 2/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.32 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RGS12 | O14924 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2992472 | 0.95 | ALOX5AP (0.32) | ALOX5APALOX5 | |
| SCHEMBL2006472 | 0.88 | ALOX5AP (0.36) | ALOX5APALOX5F2RL3LMNAMAPT | |
| SCHEMBL2006911 | 0.87 | PLA2G2A (0.37) | ALOX5APALOX5PLA2G2AF2RL3ACHE | |
| SCHEMBL2002426 | 0.85 | SLC26A4 (0.34) | ALOX5APALOX5PLA2G2AF2RL3LMNA | |
| SCHEMBL2006766 | 0.85 | F2RL3 (0.40) | ALOX5APEDNRBF2RL3ALDH1A1LMNA | |
| SCHEMBL2010346 | 0.84 | PLA2G2A (0.37) | PLA2G2AF2RL3MEN1RGS12ALDH1A1 | |
| SCHEMBL2004514 | 0.84 | F2RL3 (0.39) | ALOX5APPLA2G2AF2RL3ALDH1A1CYP1A2 | |
| SCHEMBL2005424 | 0.84 | ALOX5AP (0.42) | ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL1999823 | 0.83 | F2RL3 (0.36) | ALOX5APALOX5EDNRBF2RL3LMNA | |
| SCHEMBL2009612 | 0.83 | MEN1 (0.42) | ALOX5APALOX5PLA2G2AACHEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |