Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2008690 | 0.93 | PLA2G2A (0.38) | F2RL3PLA2G2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2006766 | 0.93 | F2RL3 (0.40) | F2RL3CYP1A2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2001047 | 0.93 | PLA2G2A (0.37) | F2RL3PLA2G2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2006329 | 0.92 | LMNA (0.38) | CYP1A2CYP3A4CYP2C9CYP2D6MAPT | |
| SCHEMBL2004225 | 0.91 | PLA2G2A (0.45) | PLA2G2ACYP1A2CYP3A4CYP2C9PTGS2 | |
| SCHEMBL2000385 | 0.91 | FAAH (0.38) | F2RL3PLA2G2AFAAH | |
| SCHEMBL2005400 | 0.90 | PPARG (0.36) | CYP1A2CYP3A4CYP2C9CYP2D6MAPT | |
| SCHEMBL2006669 | 0.90 | PLA2G2A (0.41) | F2RL3PLA2G2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2002966 | 0.89 | L3MBTL1 (0.40) | CYP1A2CYP3A4CYP2C9CYP2D6MAPT | |
| SCHEMBL2008823 | 0.89 | LMNA (0.41) | CYP1A2CYP3A4CYP2C9CYP2D6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |