Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091230 | 0.96 | FAAH (0.43) | FAAHEPHX2PTGS1PTGDR2ALDH1A1 | |
| SCHEMBL4094085 | 0.95 | L3MBTL1 (0.37) | FAAHL3MBTL1EPHX2ALDH1A1TP53 | |
| SCHEMBL4093988 | 0.91 | EPHX2 (0.36) | FAAHEPHX2ALDH1A1LMNAMAPK1 | |
| SCHEMBL4562856 | 0.87 | FAAH (0.53) | FAAHPTGS1PTGDR2TP53HTT | |
| SCHEMBL4101976 | 0.87 | FAAH (0.53) | FAAHPTGS1PTGDR2TP53HTT | |
| SCHEMBL4094189 | 0.87 | PLA2G2A (0.41) | FAAHPTGDR2ALDH1A1LMNAMEN1 | |
| SCHEMBL3011555 | 0.86 | FAAH (0.44) | FAAHL3MBTL1EPHX2PTGS1PTGDR2 | |
| SCHEMBL4093763 | 0.86 | LMNA (0.41) | EPHX2ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL4090379 | 0.86 | FAAH (0.42) | FAAHALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL2995899 | 0.86 | FAAH (0.46) | FAAHL3MBTL1PTGS1PTGDR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |