Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | SGMS1 | Q86VZ5 | 2/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | TACR2 | P21452 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392025 | 0.99 | ACHE (0.48) | ACHESGMS1SGMS2FAAHNAAA | |
| SCHEMBL4383589 | 0.96 | ACHE (0.48) | ACHESGMS1SGMS2FAAHNAAA | |
| SCHEMBL4392999 | 0.93 | ACHE (0.50) | ACHESGMS1SGMS2FAAHNAAA | |
| SCHEMBL6651781 | 0.87 | EPHX1 (0.58) | FAAHEPHX1NPC1RAB9AEPHX2 | |
| SCHEMBL11163724 | 0.86 | NPC1 (0.51) | NAAAEPHX1ALDH1A1HSD17B10NPC1 | |
| SCHEMBL11171348 | 0.85 | EPHX1 (0.56) | ACHESGMS1SGMS2FAAHEPHX1 | |
| SCHEMBL6610457 | 0.83 | POLB (0.48) | NAAALMNARAB9A | |
| SCHEMBL4383642 | 0.79 | NAAA (0.46) | NAAALMNARAB9A | |
| SCHEMBL7005662 | 0.79 | MAPT (0.59) | ACHESGMS1SGMS2FAAHEPHX1 | |
| SCHEMBL27416354 | 0.75 | ALDH1A1 (0.49) | ACHEESR1ADRA2AADORA3TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |