SCHEMBL4384546

SCHEMBL4384546

Cc1cc(C(=C=O)CN(C)C)c(C)o1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.49
KDM4E B2RXH2 1/20 0.49
RAB9A P51151 4/20 0.44
ALDH1A1 P00352 5/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
HPGD P15428 2/20 0.40
TP53 P04637 1/20 0.38
HSD17B10 Q99714 1/20 0.38
ALPL P05186 1/20 0.38
ALOX5 P09917 1/20 0.37
NPC1 O15118 3/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
HTT P42858 2/20 0.37
POLB P06746 1/20 0.37
APOBEC3A P31941 1/20 0.37
CTDSP1 Q9GZU7 1/20 0.37
APOBEC3G Q9HC16 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6970001 0.70 CYP2C9 (0.34) MAPTRAB9AALDH1A1ALOX5NPC1
SCHEMBL3173668 0.67 MAPT (0.58) MAPTKDM4ERAB9AALDH1A1SMN1; SMN2
SCHEMBL12086352 0.67 MAPT (0.58) MAPTKDM4ERAB9AALDH1A1SMN1; SMN2
SCHEMBL4338338 0.66 MAPT (1.00) MAPTKDM4ERAB9AALDH1A1SMN1; SMN2
SCHEMBL6982496 0.66 GSK3B (0.45) MAPTKDM4ERAB9AALDH1A1SMN1; SMN2
SCHEMBL4592149 0.65 GAA (0.50) KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10
SCHEMBL5763247 0.65 TDP1 (0.37) MAPTKDM4EALDH1A1MEN1KMT2A
SCHEMBL3411109 0.64 POLB (0.44) MAPTKDM4EALDH1A1HPGDTP53
SCHEMBL8985731 0.64 MAPT (0.48) MAPTKDM4ERAB9AALDH1A1SMN1; SMN2
SCHEMBL260904 0.64 MAPT (0.59) MAPTKDM4ERAB9AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009109991-A2 NOVEL HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS SUN PHARMA ADVANCED RESEARCH COMPANY LTD., (IN) 2009-09-11 WO disclosed